Our Latest Podcasts

• Episode 27 – Using Artificial Intelligence to speed Alzheimer’s studies

  This week, Shanti and Eliot talk to founder and CEO of Unlearn, Charles Fisher. They discuss how artificial intelligence can effect Alzheimer's drug research.

• Episode 26 – A diagnostic test for Alzheimer’s disease

  Episode Notes Shanti and Elliot talk to Dr. James Kupiec about a diagnostics test for Alzheimer's disease.

• Episode 25 – Trusting Covid-19 antibody testing—the CDC weighs in

  Episode Notes Shanti and Elliot discuss recent developments in antibody testing for Covid-19

• Episode 24 – New Ways to Attack ALS and Other Protein Misfolding Diseases with Johanne Kaplan

  Elliot and Shanti talk to Johanne Kaplan about a new way to attack ALS and other protein misfolding diseases,

• Episode 23 – Introducing Intrabodies with Dr. Johanne Kaplan.

  This week Shanti and Elliot discuss Intrabodies with Dr. Johanne Kaplan

• Episode 22 – Worried about aducanumab? Don’t be. Dr. Jim Kupiec explains

  Dr. Jim Kupiec explains why there is nothing to worry about regarding the recent news about aducanumab.

• Episode 21 – “For a COVID-19 antibody test, selectivity is key.”

  Shanti and Elliot announce that ProMIS is beginning to develop a test for Covid-19. They discuss how ProMIS can leverage its existing expertise.

• *Re-Release* Episode 4 – How do Biomarkers Work?

  We are re-releasing a popular episode about Biomarkers and how they work!

• Episode 20 –Dr. José Luis Molinuevo of the BarcelonaBeta Brain Research Center on the Future of Alzheimer's Disease

  Shanti and Elliot talk to Dr. José Luis Molinuevo of the BarcelonaBeta Brain Research Center on the Future of Alzheimer's Disease

• Episode 19 – Dr. Stephen Salloway, Rhode Island’s Man of the Year, on a brighter future for Alzheimer’s disease

  Dr. Stephen Salloway and Dr. James Kupiec reflect on Aducanumab, the exciting progress that has been made in the AD research community over the last 20 years, and the future of AD research.

• Episode 18 – Dr. Sharon Cohen Deconstructs the Aducanumab Data From CTAD

  This week Shanti and Elliot talk to Dr. Sharon Cohen, director of Toronto Memory Program. They discuss the recent news surrounding aducanumab, as well as Dr. Cohen's recent trip to CTAD.

• Episode 17 – The Data Behind Biogen's Recent Decision with Dr. James Kupiec

  This week Shanti and Elliot discuss the data behind Biogen's recent decision to revive their Aducanumab study.

• Episode 16 – In the news: Biogen and Neuroinflammation with Dr. Johanne Kaplan

  This week Shanti and Johanne discuss the recent news coming out of Biogen and how Neuroinflammation relates to Alzheimer's.

• Episode 15 – Protein Misfolding Diseases with Dr. Lary Walker

  This week Shanti and Elliot talk to Dr. Lary Walker, a research professor at Emory University. They discuss what Alzheimer’s, Parkinson’s and more have in common.

• Episode 14 – Finding Treatment for Alzheimer's and Other Diseases with Brain Canada's Inez Jabalpurwala

  This week Shanti and Elliot are joined by Brain Canada's CEO Inez Jabalpurwala. They discuss the wonderful work that Brain Canada has been doing, and the next steps in the search for a cure for Alzheimer's, Parkinson's and other diseases.

• Episode 13 – Understanding Multiple System Atrophy, Prions and Neuron Death

  This week Shanti and Elliot discuss Multiple System Atrophy, prions and how greater understanding of each can help other neurodegenerative diseases.

• Episode 12 – A Deeper Dive Into Biomarkers with Dr. James Kupiec Reporting on AAIC Research

  This week Shanti is joined by Dr. James Kupiec, Chief Medical Officer at ProMIS Neurosciences. Shanti and Dr. Kupiec do a deep dive on Biomarkers and discuss recent research coming out of AAIC.

• Episode 11 – What Is TDP43 and What Are We Going to Do About It?

  Elliot is back to discuss the TDP43 protein, which has been implicated in the development of a recently discovered form of dementia as well as ALS. Shanti and Elliot talk about why TDP43 is important, and the efforts to neutralize the misfolded protein in the brain before it can destroy brain cells.

• Episode 10 – AAIC 2019 Recap with Dr. Johanne Kaplan

  This week Shanti and Dr. Johanne Kaplan recap AAIC 2019 and discuss the exciting data that came out of the conference. For more information check out https://promisneurosciences.com/

• Episode 9 – AAIC 2019 Preview with Dr. Johanne Kaplan

  This week Shanti and Johanne preview AAIC and discuss what the hot topics at the conference are expected to be.

• Episode 8 – 2019 Keystone Symposia Breakdown with Dr. Johanne Kaplan

  This week Shanti discusses some of the most exciting news coming out of the recent 2019 Keystone Symposia with Dr. Johanne Kaplan.

• Episode 7 – Dr. Johanne Kaplan on the Importance of Selectivity

  Shanti is joined by Dr. Johanne Kaplan, the Chief Development Officer at ProMIS Neurosciences. The two discuss Dr. Kaplan's career, and the current challenges researchers must tackle as they continue their search for a way to stop Alzheimer's disease. The two also discuss Dr. Kaplan's recent paper on the importance of selectivity in drug development…

• Episode 6 – The "One-Two Punch" of Abeta and Tau

  Toxic tau and amyloid-beta are the two most validated drug targets for an Alzheimers disease therapy. Elliot and Shanti discuss tau, its role as a root cause of Alzheimer's disease and its involvement in 80 other diseases known as tauopathies.

• Episode 5 – Major Late-stage Alzheimer's Failures

  Dr. Goldstein and Shanti breakdown the news of the week. This week they discuss two major late-stage failures for promising Alzheimer's drugs, a new syndrome that is similar to Alzheimer's, and some important biomarker developments.

• Episode 4 – How do Biomarkers Work?

  This is part two of our exploration of biomarkers. Elliot and Shanti discuss how biomarkers work and how they will play a critical role in the future of drug development for the various brain-wasting diseases.