Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

Williams Eugene

2. Date of Event Requiring Statement (Month/Day/Year)
07/07/2022

3. Issuer Name and Ticker or Trading Symbol
ProMIS Neurosciences Inc. [PMN]

(Last)

(First)

(Middle)

C/O PROMIS NEUROSCIENCES INC.,, 1920 YONGE STREET, SUITE 200

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

__X__ Director	_____ 10% Owner
__X__ Officer (give title below)	_____ Other (specify below)
Chairman and CEO

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

TORONTO, A6 M4S 3E2

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Shares	153,930	D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Option (right to buy)	⁽²⁾	07/06/2025	Common Shares	78,822	$ 2.43 ⁽¹⁾	D
Option (right to buy)	⁽³⁾	07/31/2025	Common Shares	36,988	$ 3.9 ⁽¹⁾	D
Option (right to buy)	⁽⁴⁾	03/29/2028	Common Shares	16,667	$ 28.2 ⁽¹⁾	D
Option (right to buy)	⁽⁵⁾	02/10/2032	Common Shares	50,000	$ 8.4 ⁽¹⁾	D
Warrants (right to buy)	08/09/2017	08/09/2022	Common Shares	833	$ 18 ⁽¹⁾	D
Warrants (right to buy)	04/30/2018	04/30/2023	Common Shares	556	$ 28.8 ⁽¹⁾	D
Warrants (right to buy)	01/22/2019	01/22/2024	Common Shares	1,927	$ 28.8 ⁽¹⁾	D
Warrants (right to buy)	05/31/2019	12/31/2024	Common Shares	1,111	$ 21 ⁽¹⁾	D
Warrants (right to buy)	03/05/2021	11/05/2026	Common Shares	3,472	$ 12 ⁽¹⁾	D

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
Williams Eugene C/O PROMIS NEUROSCIENCES INC., 1920 YONGE STREET, SUITE 200 TORONTO, A6 M4S 3E2	X		Chairman and CEO

Signatures

/s/ Jason L. Langford, Attorney-in-Fact for Eugene Williams		07/07/2022
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Conversion or exercise price is in Canadian dollars.
(2)	The option agreement provides that the option vested 1/4 immediately with the balance vesting ratably over 36 months. The option was granted on July 6, 2015.
(3)	The option agreement provides that the option vested 1/4 immediately with the balance vesting ratably over 36 months. The option was granted on July 31, 2015.
(4)	The option agreement provides that the option vested 1/4 immediately with the balance vesting ratably over 36 months. The option was granted on March 29, 2018.
(5)	The option agreement provides that the options become exercisable in 48 equal monthly installments beginning one month after the grant. The option was granted on February 10, 2022.
Remarks: Exhibit List: Exhibit 24 - Power of Attorney

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