Ownership Submission

FORM 3

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940

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3235-0104

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(Print or Type Responses)

1. Name and Address of Reporting Person ^*

WYMAN WILLIAM W

2. Date of Event Requiring Statement (Month/Day/Year)
07/07/2022

3. Issuer Name and Ticker or Trading Symbol
ProMIS Neurosciences Inc. [PMN]

(Last)

(First)

(Middle)

C/O PROMIS NEUROSCIENCES, INC., 1920 YONGE STREET, SUITE 200

4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

__X__ Director	_____ 10% Owner
_____ Officer (give title below)	_____ Other (specify below)

5. If Amendment, Date Original Filed(Month/Day/Year)

(Street)

TORONTO, A6 M4S 3E2

6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

(City)

(State)

(Zip)

Table I - Non-Derivative Securities Beneficially Owned

1.Title of Security (Instr. 4)	2. Amount of Securities Beneficially Owned (Instr. 4)	3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5)	4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Shares	62,937	D

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.			SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)

1. Title of Derivative Security (Instr. 4)	2. Date Exercisable and Expiration Date (Month/Day/Year)		3. Title and Amount of Securities Underlying Derivative Security (Instr. 4)		4. Conversion or Exercise Price of Derivative Security	5. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 5)	6. Nature of Indirect Beneficial Ownership (Instr. 5)
1. Title of Derivative Security (Instr. 4)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares	4. Conversion or Exercise Price of Derivative Security		6. Nature of Indirect Beneficial Ownership (Instr. 5)
Option (right to buy)	⁽²⁾	03/08/2024	Common Shares	3,333	$ 4.8 ⁽¹⁾	D
Option (right to buy)	⁽³⁾	10/07/2025	Common Shares	4,167	$ 4.89 ⁽¹⁾	D
Option (right to buy)	⁽⁴⁾	09/19/2026	Common Shares	4,167	$ 9.6 ⁽¹⁾	D
Option (right to buy)	⁽⁵⁾	03/30/2031	Common Shares	8,333	$ 10.2 ⁽¹⁾	D
Warrants (right to buy)	04/30/2018	04/30/2023	Common Shares	2,778	$ 28.8 ⁽¹⁾	D
Warrants (right to buy)	02/05/2021	03/05/2026	Common Shares	4,549	$ 12 ⁽¹⁾	D

Reporting Owners

Reporting Owner Name / Address	Relationships
Reporting Owner Name / Address	Director	10% Owner	Officer	Other
WYMAN WILLIAM W C/O PROMIS NEUROSCIENCES INC., 1920 YONGE STREET, SUITE 200 TORONTO, A6 M4S 3E2	X

Signatures

/s/ Jason L. Langford, Attorney-in-Fact for William W. Wyman		07/07/2022
^**Signature of Reporting Person		Date

Explanation of Responses:

*	If the form is filed by more than one reporting person, see Instruction 5(b)(v).
**	Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1)	Conversion or exercise price is in Canadian dollars.
(2)	The options immediately vested.
(3)	The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on October 7, 2015.
(4)	The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on September 19, 2016.
(5)	The option agreement provides that 25% of the options vest immediately, with the remainder vesting ratably over the next three quarters. The option was granted on March 30, 2021.
Remarks: Exhibit List: Exhibit 24 - Power of Attorney

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